Three weight-loss tablets are licensed in the UK: the Wegovy pill, Foundayo and orlistat. Each is supplied by Solira after an online consultation reviewed by a GPhC-registered pharmacist, and posted by tracked delivery in plain packaging. Here is how they compare.
oral semaglutide
The same GLP-1 medicine as the Wegovy injection, as a once-daily tablet, licensed for weight loss.
orforglipron
A once-daily oral GLP-1 medicine, licensed in the UK in August 2026 for weight management.
120mg on prescription, or alli 60mg
Not a GLP-1 medicine: it works in the gut, reducing how much of the fat in your meals your body absorbs.
| Wegovy pill | Foundayo | Orlistat | |
|---|---|---|---|
| Type | GLP-1 medicine | GLP-1 medicine | Fat absorption blocker |
| How often | Once a day | Once a day | Up to three a day, with meals |
| Food rules | Empty stomach, wait 30 minutes | None | With a meal that contains fat |
| Doses | 1.5mg, 4mg, 9mg, 25mg | 0.8mg up to 17.2mg | 120mg or 60mg |
| Price | From £79.99 / 30 days | From £79.99 / 30 days | £26.99 / 84 capsules |
| Video call | Before your first supply | Before your first supply | 120mg only |
Prices are per supply, before £2.99 delivery. Every dose and price is on each medicine's own page. Considering an injection instead? See all weight-loss treatments, including Mounjaro and the Wegovy injection.
You may be able to carry on at your current dose. Upload proof of your current treatment during your consultation, and your pharmacist checks it before anything is supplied.
In their main trials, average weight loss was about 14% with the Wegovy tablet and about 15% with the 2.4mg Wegovy injection, but these were separate trials, so the figures are not a direct comparison. The injection is weekly; the tablets are daily and needle-free. The best choice depends on your preferences and medical history, and your pharmacist can talk it through with you. More in Wegovy pill vs injection.
For the Wegovy pill: Treatment may be suitable if you're aged 18–85 and have a BMI of 30 or above, or a BMI of 27–29.9 alongside one of the following: type 2 diabetes, prediabetes or impaired glucose tolerance, metabolic syndrome, high blood pressure, raised cholesterol or blood fats, cardiovascular disease, coronary heart disease, obstructive sleep apnoea, an obstructive lung condition such as COPD, non-alcoholic fatty liver disease, osteoarthritis, polycystic ovary syndrome (PCOS), or fertility difficulties linked to weight.
Foundayo is licensed for adults with a BMI of 30 or above, or a BMI of 27 to 30 with at least one weight-related condition such as high blood pressure or type 2 diabetes. Orlistat 120mg is for adults aged 18 to 75 with a BMI of 30 or above, or 28 or above with type 2 diabetes, high blood pressure or high cholesterol; orlistat 60mg (alli) is for adults with a BMI of 28 or above.
Not sure of your BMI? Check it hereStop your treatment and seek urgent medical help if you experience: severe, persistent stomach pain, especially spreading to your back, with or without vomiting. This can be a sign of pancreatitis. Sudden pain in the upper right of your tummy, fever, or yellowing of the skin or eyes: possible gallbladder problems. Sudden loss of vision, or loss of part of your field of vision: seek same-day eye assessment. Swelling of the face or lips, difficulty breathing, or a widespread rash: call 999.
Seek advice promptly if you notice: signs of dehydration during vomiting or diarrhoea (dizziness, reduced urination, dry mouth): keep sipping fluids, as dehydration can affect your kidneys; palpitations or a racing heartbeat at rest; a new neck lump, swelling, or hoarseness. If you have type 2 diabetes and use insulin or a sulfonylurea, know the signs of low blood sugar (sweating, shaking, sudden hunger, confusion) and treat promptly.
Before any operation: tell your surgical or anaesthetic team you take a GLP-1 medicine. It slows stomach emptying, which matters for anaesthesia.
Three kinds of weight-loss tablet are licensed in the UK and supplied by Solira after a pharmacist review: the Wegovy pill (oral semaglutide), a once-daily GLP-1 tablet approved in June 2026; Foundayo (orforglipron), a once-daily GLP-1 tablet licensed in August 2026; and orlistat, a capsule taken with meals, as 120mg on prescription or as alli 60mg from a pharmacy.
In their main trials, counting everyone who started treatment: adults on the Wegovy pill 25mg lost an average of 13.6% of their body weight over 64 weeks (OASIS 4); adults on Foundayo lost 7.5%, 8.4% and 11.2% at the doses matching 5.5mg, 9mg and 17.2mg over 72 weeks (ATTAIN-1); and adults on orlistat 120mg lost an average of 5.8kg over four years, against 3.0kg on placebo (XENDOS). These were separate trials in different people, so the figures are not a direct comparison, and individual results vary. Each works alongside diet and activity, not instead of them.
The Wegovy pill and Foundayo are GLP-1 medicines: they act like GLP-1, a natural gut hormone, reducing appetite and slowing how quickly the stomach empties, so you feel full for longer. Orlistat works differently. It blocks an enzyme in the gut that breaks down fat, so about a third of the fat in your meals at 120mg, or about a quarter at 60mg, passes out of the body instead of being absorbed. Each works alongside diet and activity, not instead of them.
Both are once-daily GLP-1 tablets. The Wegovy pill is semaglutide, the same medicine as the Wegovy injection, and has to be taken on an empty stomach with a 30-minute wait before eating or drinking. Foundayo is orforglipron, a different GLP-1 medicine, and can be taken at any time of day with no food or water restriction. Your pharmacist can help you decide which suits you.
In their main trials, average weight loss was about 14% with the Wegovy tablet and about 15% with the 2.4mg Wegovy injection, but these were separate trials, so the figures are not a direct comparison. The injection is weekly; the tablet is daily and needle-free. The best choice depends on your preferences and medical history.
The Wegovy pill and Foundayo mostly cause gut side effects, which are most noticeable while the dose is increasing and usually settle. With the Wegovy pill, headache, nausea, vomiting, diarrhoea, constipation, indigestion, stomach pain and feeling weak or tired affect more than 1 in 10 people. With Foundayo, the most common are nausea, constipation, diarrhoea, vomiting, indigestion and stomach pain. With orlistat, common side effects include oily or fatty stools, oily spotting, wind with discharge, and needing the toilet urgently or more often. They are more likely after a meal high in fat. Your pharmacist will discuss potential side effects during the consultation.
The Wegovy pill, Foundayo and orlistat are licensed medicines, but they are not suitable for everyone. That is why our pharmacist checks your health, medical history and other medicines against the licence for the tablet you choose before anything is supplied. Get them only from a registered pharmacy: the MHRA warns that weight-loss medicines sold through salons, social media or websites that skip a consultation may be fake, contaminated or wrongly dosed.
At Solira, per 30-day supply: the Wegovy pill from £79.99 and Foundayo from £79.99, rising with each dose step. Orlistat 120mg is £26.99 for 84 capsules and alli 60mg is £42.99. Delivery is £2.99. A pharmacist review is included, with no separate consultation fee. The price for each dose is the same on your first order and every one after. No introductory prices.
The Wegovy pill, Foundayo and orlistat 120mg are prescription-only medicines. Solira supplies them after an online consultation reviewed by a GPhC-registered pharmacist, where it is clinically suitable, with no GP referral needed. Orlistat 60mg (alli) is a pharmacy medicine, supplied after a pharmacist consultation.
Of these three, only orlistat 60mg (alli). It is a pharmacy medicine, so you can buy it without a prescription after a pharmacist consultation. The Wegovy pill, Foundayo and orlistat 120mg are prescription-only, so they are supplied only after a prescriber has reviewed your consultation.
The Wegovy pill and Foundayo are not currently available on the NHS for weight management; any NHS availability would follow a separate national assessment. Both are available privately through registered pharmacies, including QuickCare Pharmacy through Solira, for eligible patients.
For the Wegovy pill: Treatment may be suitable if you're aged 18–85 and have a BMI of 30 or above, or a BMI of 27–29.9 alongside one of the following: type 2 diabetes, prediabetes or impaired glucose tolerance, metabolic syndrome, high blood pressure, raised cholesterol or blood fats, cardiovascular disease, coronary heart disease, obstructive sleep apnoea, an obstructive lung condition such as COPD, non-alcoholic fatty liver disease, osteoarthritis, polycystic ovary syndrome (PCOS), or fertility difficulties linked to weight. Foundayo is licensed for adults with a BMI of 30 or above, or 27 to 30 with at least one weight-related condition. Orlistat 120mg is for adults aged 18 to 75 with a BMI of 30 or above, or 28 or above with type 2 diabetes, high blood pressure or high cholesterol. Your pharmacist checks your answers against the licence before anything is supplied.
Free, takes a few minutes, reviewed by a UK pharmacist.