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Great service
Great service as always.
Abu Siddique18 Apr 2026
Weight Loss
Orlistat
Clinically proven oral weight loss capsules, available in 60mg (pharmacy) and 120mg (prescription strength)
Start consultationGPhC registered pharmacy
Pharmacist reviewed
Discreet delivery
How it works
Blocking fat absorption at source
Orlistat is a lipase inhibitor. It works in the gut to block the enzyme that breaks down dietary fat. Approximately one third of the fat you eat is prevented from being absorbed and is instead passed out of the body. Unlike GLP-1 medications, orlistat does not affect appetite or the brain. It works directly in the digestive system to reduce calorie absorption from fat.
1/3
of dietary fat absorption blocked
0kg
Average additional weight loss vs diet alone at 12 months (NICE data)
1998
Licensed in the UK since
Available strengths
Choose the right strength for you
Pharmacy strength
Orlistat 60mg (Orlos)
No prescription required
Available without a doctor's prescription after a pharmacist assessment. Suitable for BMI ≥28.
From £24.99 per pack (84 capsules)
Start consultation →Prescription strengthOrlistat 120mg
Prescription required
The stronger prescription dose for clinically obese patients. Reviewed and prescribed by our GPhC-registered pharmacist. Suitable for BMI ≥28.
From £39.99 per pack (84 capsules)
Start consultation →Clinical evidence
Proven over 25 years
Orlistat 120mg has been licensed in the UK since 1998. The pivotal XENDOS trial (Torgerson et al. Diabetes Care, 2004) followed 3,305 patients over 4 years and demonstrated that orlistat combined with lifestyle modification produced significantly greater weight loss than lifestyle modification alone, and reduced the risk of developing type 2 diabetes by 37.3% in patients with impaired glucose tolerance. NICE recommends orlistat as a first-line adjunct to diet and exercise for patients with a BMI ≥28 with risk factors, or BMI ≥30.
Source: Torgerson JS et al. Diabetes Care 2004; NICE CG189 Obesity Management 2014 (updated 2023)
Important information
What you need to know before starting orlistat
Diet is essential
Orlistat works alongside a calorie-controlled diet with no more than 30% of calories from fat. Without dietary change, side effects increase significantly.
Take a multivitamin
Orlistat reduces absorption of fat-soluble vitamins (A, D, E, K). Take a daily multivitamin at least 2 hours after your orlistat dose or at bedtime.
Side effects are manageable
Oily stools, flatulence, and urgency are common, particularly if dietary fat intake is high. Following a low-fat diet minimises these effects significantly.
12-week review
Treatment is reviewed at 12 weeks. If you have not lost at least 5% of your starting body weight, treatment should be discontinued.
Side effects
What to expect
Most side effects of orlistat are gastrointestinal and directly related to the mechanism of action. They occur when dietary fat intake is high. Following the recommended low-fat diet substantially reduces their likelihood and severity.
Very common (more than 1 in 10)
Oily or fatty stools · Increased frequency of bowel movements · Flatulence with discharge · Oily spotting from the rectum · Faecal urgency · Abdominal discomfort · Headache
Common (up to 1 in 10)
Faecal incontinence · Soft stools · Abdominal distension · Rectal discomfort · Urinary tract infection · Fatigue · Menstrual irregularity
Report any unexpected or severe side effects to our pharmacist or your GP. Suspected adverse reactions can be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.
Pricing
Orlistat pricing
New patient
84 capsules
1 pack
£24.99
+ £3.99 delivery
Start assessment168 capsules
2 packs
£44.99
+ £3.99 delivery
Start assessment252 capsules
3 packs
£64.99
+ £3.99 delivery
Start assessmentNo prescription required. Pharmacist assessment required before each order.
FAQ
Common questions
Alli contains orlistat 60mg and Orlos is a branded version of orlistat 60mg. They are therapeutically identical. Our 60mg capsules are the same active ingredient at the same dose.
Orlistat works immediately, from the first dose it begins blocking approximately one third of dietary fat absorption. Weight loss typically becomes visible within 2 to 4 weeks when combined with a calorie-controlled diet.
Some medications interact with orlistat. Our pharmacist will review your medication list during the consultation. Key interactions include ciclosporin, amiodarone, warfarin, levothyroxine, and some epilepsy medications.
A calorie-controlled diet with no more than 30% of calories from fat. Spreading fat intake evenly across meals helps minimise gastrointestinal side effects. Your pharmacist can provide dietary guidance.
Treatment is reviewed at 12 weeks. If you have lost at least 5% of your starting body weight, treatment can be continued. If not, it should be discontinued and alternative options considered.
Patient reviews
Trusted by real patients
Trustpilot
Lovely & genuine service
Thanks to Jimah, he really looked after me and my family. Totally recommend everyone to give him a shout and speak to him. Lovely & genuine person. Thank you once again!!
Chadz17 Apr 2026
Trustpilot
Excellent service
Excellent service in receiving my Mounjaro prescription. Very efficient and love the prices! Hope they are able to maintain this level of service moving forward.
Lara Gray15 Apr 2026
Trustpilot
Switched from Boots
Was on Wegovy with Boots for 5 months before switching to Solira. Much better prices and excellent customer service experience!
Hannah G15 Apr 2026
Trustpilot
Amazing experience
Amazing experience. Jimah is very attentive and has all the answers to my questions. Highly recommend Solira, transparent pricing and honest.
S A14 Apr 2026
Trustpilot
Very happy with the service
Very happy with the service. Received my weight loss treatment incredibly quickly and much better value for money in comparison to others I've had a look at.
Samir S14 Apr 2026
Trustpilot
Diligent pharmacist
My pharmaceutical advisor was very diligent in helping me understand what was essential and what was helpful when addressing my personal health issue. I'm very happy with my choice and will be using this company going forward.
Connor13 Apr 2026
Trustpilot
Highly recommend to everyone
Highly recommend this company! I had great results with my weight loss treatment and excellent service throughout! The clinical lead Jimah is really clued on with everything and answered all of my queries and gave me the reassurance I needed! Delivery speed was great as well.
Maruf Choudhury7 Apr 2026
Trustpilot
Really happy so far
Really happy with the service so far. It's been easy to use, communication has been good, and I'm seeing steady progress with my weight loss. Glad I decided to give it a try.
Adam R.7 Apr 2026
Trustpilot
Excellent weight loss service
Brilliant service with my weight loss treatment, excellent customer service throughout with fast next day delivery.
Jim7 Apr 2026
Start your weight loss journey
A private, clinical service, reviewed by a GPhC-registered pharmacist
Start orlistat consultation