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    Erectile Dysfunction

    Sildenafil

    Sildenafil tablets for erectile dysfunction, the active ingredient in Viagra. A GPhC-registered pharmacist reviews every request.

    GPhC registeredPharmacist reviewedDiscreet packaging
    Excellent 4.6 out of 5 on Trustpilot(opens Trustpilot in a new tab)
    Illustration of a blue diamond-shaped tablet
    Three strengths

    25mg , 50mg , 100mg

    Takes effect
    About 1 hr
    Lasts
    Short acting
    Price per tablet
    From £0.81
    About

    What is Sildenafil

    Sildenafil is a PDE5 inhibitor, the same active ingredient found in Viagra. It works by increasing blood flow to the penis when sexually stimulated, helping you achieve and maintain an erection. It is fully licensed in the UK and available in 25mg, 50mg, and 100mg tablets.

    1. Sexual stimulation
    2. Nitric oxideis released
    3. cGMPrelaxes the blood vesselsPDE5 inhibitors slow the breakdown of cGMP
    4. Blood flowto the penis increases
    How PDE5 inhibitors such as sildenafil work. Sexual stimulation is still required.
    Value

    Same medicine. A fraction of the price.

    Branded Viagra£8 to 15 per tablet
    Generic SildenafilFrom £0.81 per tablet

    Generic sildenafil contains the identical active ingredient at the same dose as Viagra, manufactured to identical pharmaceutical standards and licensed by the MHRA. The only difference is the price.

    How it works

    Three simple steps

    Step 1

    Complete your consultation. Answer a short, confidential questionnaire about your health and symptoms.

    Step 2

    Prescriber review. A GPhC-registered pharmacist reviews your consultation within 24 hours.

    Step 3

    Discreet delivery. If approved, your medication is delivered in plain packaging, with no medicine names on the outside.

    Clinical evidence

    25 years of clinical data

    Sildenafil was the first oral PDE5 inhibitor licensed for erectile dysfunction, approved in the UK in 1998. In a 12-week trial reported in the New England Journal of Medicine in 1998, 69% of attempts at intercourse were successful for men taking sildenafil at doses adjusted between 25mg and 100mg, compared with 22% on placebo. Individual results vary.

    Sources

    • Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. NEJM 1998. doi.org
    Attempts at intercourse that were successful, 12-week trial
    Sildenafil, 25mg to 100mg69%
    Placebo22%

    Goldstein I et al. NEJM 1998

    About 1 hourTime to work
    69%of attempts successful on 25mg to 100mg, vs 22% on placebo
    Suitability

    Who it's for

    Sildenafil is suitable for adult men experiencing erectile dysfunction. Your prescriber will assess your suitability based on your medical history.

    Not suitable if you take:

    • Nitrates (GTN spray, isosorbide mononitrate/dinitrate)
    • Riociguat (Adempas) or vericiguat (Verquvo)
    • Or have severe cardiovascular disease
    Dosing

    How to take Sildenafil

    • Starting dose: 50mg
    • Take it about 1 hour before sex (anywhere from 30 minutes to 2 hours before)
    • Maximum one tablet per day
    • Do not take with grapefruit juice
    25mg50mgStart100mg
    1. Take it

      Take it about 1 hour before sex (anywhere from 30 minutes to 2 hours before)

    2. About 1 hour

      It takes about an hour to work. A heavy or high-fat meal can delay how quickly it works.

    When to take sildenafil and when it starts to work. Maximum one tablet per day.
    Advice

    Before you take it

    • Take it about 1 hour before sex (anywhere from 30 minutes to 2 hours before). It takes about an hour to work.
    • Sildenafil: avoid grapefruit and grapefruit juice.
    • These tablets only work with sexual stimulation.
    • Most men notice an effect the first or second time. If not, try it 4 to 8 times before deciding it does not work, then tell us.
    • If this is your first time with erection problems, see your GP to check your blood sugar, cholesterol and testosterone, and have a heart health check at least every 5 years.
    • These tablets can affect your ability to drive or use machines.
    • Do not use unlicensed herbal remedies for erections, and do not stop any prescribed medicine unless your doctor tells you to.
    • Losing weight, stopping smoking, drinking less alcohol and exercising can all help. If you cycle more than 3 hours a week, try a break from cycling.
    • A heavy or high-fat meal can delay how quickly sildenafil, vardenafil and avanafil work. Tadalafil is not affected by food.
    • Tell us or your GP about any side effect. You can also report it to the MHRA Yellow Card scheme.
    Pricing

    Sildenafil pricing

    8 tablets per order

    Delivery £2.99

    Side effects

    Very common / common side effects include headache, dizziness, flushing, nasal congestion, dyspepsia (indigestion), nausea and vision disturbances. Less common side effects are listed in the leaflet in your pack. Please read it before your first dose.

    Rare but serious: priapism

    Seek emergency medical treatment if you experience an erection lasting more than 4 hours.
    FAQ

    Common questions

    Yes. Sildenafil is the identical active ingredient in Viagra. Generic sildenafil performs identically at a fraction of the branded price.

    Take it about 1 hour before sex (anywhere from 30 minutes to 2 hours before). It takes about an hour to work. A heavy or high-fat meal can delay how quickly it works.

    This depends on the nature and severity of your condition. Sildenafil may be suitable if your blood pressure is controlled, you have mild heart valve disease or mild heart failure that does not limit your everyday activity, or you have had a successful bypass, stent or angioplasty. It is not suitable within 6 months of a heart attack or stroke, with unstable angina or angina during sex, or if a doctor has told you sex is not safe for you. Men who take nitrates cannot take it. Your prescriber will assess your cardiovascular history carefully.

    Drinking less alcohol can help your erections.

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